BAKER BROS. ADVISORS LP — INSMED INCORPORATED INSM: Quarterly 13F Position History
BAKER BROS. ADVISORS LP has reported INSMED INCORPORATED (INSM) on 41 13F-HR filings in Pactolio's tracked window, first appearing in Q1 2016. As of Q1 2026, the position is sized at 7,421,111 shares ($1.21B market value, 6.97% of the equity book). Quarter-over-quarter share count change: + 828,365 (+12.6%) .
- 7,421,111Shares Held (Latest Filing)
- $1.21BReported Market Value (Latest Filing)
- 6.97%Portfolio Weight (% of 13F Equity Book)
- +828,365Quarter-over-Quarter Share Change
- +$66.1MQuarter-over-Quarter Value Change
- 7,712,900Peak Reported Shares (Historical)
Quarterly 13F-HR Disclosure History Source: SEC 13F-HR filings, 41 quarter s
| Quarter | Shares | QoQ Share Change | Share Change (%) | Market Value | Weight | Implied Price |
|---|---|---|---|---|---|---|
| Q1 2026 | 7,421,111 | +828,365 | +12.6% | $1.21B | 6.97% | $163.52 |
| Q4 2025 | 6,592,746 | 110,738 | -1.7% | $1.15B | 6.72% | $174.04 |
| Q3 2025 | 6,703,484 | 1,009,416 | -13.1% | $965.4M | 6.98% | $144.01 |
| Q2 2025 | 7,712,900 | +2,332,274 | +43.3% | $776.2M | 7.53% | $100.64 |
| Q1 2025 | 5,380,626 | +373,763 | +7.5% | $410.5M | 4.54% | $76.29 |
| Q4 2024 | 5,006,863 | +590,945 | +13.4% | $345.7M | 3.69% | $69.04 |
| Q3 2024 | 4,415,918 | +839,880 | +23.5% | $322.4M | 3.34% | $73.00 |
| Q2 2024 | 3,576,038 | +3,233,038 | +942.6% | $239.6M | 3.06% | $67.00 |
| Q1 2024 | 343,000 | 0 | — | $9.3M | 0.12% | $27.13 |
| Q4 2023 | 343,000 | 0 | — | $10.6M | 0.12% | $30.99 |
| Q3 2023 | 343,000 | 0 | — | $8.7M | 0.05% | $25.25 |
| Q2 2023 | 343,000 | 0 | — | $7.2M | 0.04% | $21.10 |
| Q1 2023 | 343,000 | +323,050 | +1619.3% | $5.8M | 0.03% | $17.05 |
| Q4 2022 | 19,950 | 0 | — | $398.6K | 0.00% | $19.98 |
| Q3 2022 | 19,950 | 2,136,051 | -99.1% | $430.0K | 0.00% | $21.55 |
| Q2 2022 | 2,156,001 | 0 | — | $42.5M | 0.24% | $19.72 |
| Q1 2022 | 2,156,001 | 0 | — | $50.7M | 0.29% | $23.50 |
| Q4 2021 | 2,156,001 | 0 | — | $58.7M | 0.29% | $27.24 |
| Q3 2021 | 2,156,001 | 0 | — | $59.4M | 0.26% | $27.54 |
| Q2 2021 | 2,156,001 | 0 | — | $61.4M | 0.27% | $28.46 |
| Q1 2021 | 2,156,001 | 0 | — | $73.4M | 0.32% | $34.06 |
| Q4 2020 | 2,156,001 | 116,711 | -5.1% | $71.8M | 0.27% | $33.29 |
| Q3 2020 | 2,272,712 | 752,672 | -24.9% | $73.0M | 0.29% | $32.14 |
| Q2 2020 | 3,025,384 | 0 | — | $83.3M | 0.37% | $27.54 |
| Q1 2020 | 3,025,384 | +580,119 | +23.7% | $48.5M | 0.30% | $16.03 |
| Q4 2019 | 2,445,265 | +215,505 | +9.7% | $58.4M | 0.31% | $23.88 |
| Q3 2019 | 2,229,760 | 232,456 | -9.4% | $39.3M | 0.27% | $17.64 |
| Q2 2019 | 2,462,216 | +384,615 | +18.5% | $63.0M | 0.43% | $25.60 |
| Q1 2019 | 2,077,601 | +225,619 | +12.2% | $60.4M | 0.39% | $29.07 |
| Q4 2018 | 1,851,982 | 0 | — | $24.3M | 0.20% | $13.12 |
| Q3 2018 | 1,851,982 | +1,151,982 | +164.6% | $37.4M | 0.25% | $20.22 |
| Q2 2018 | 700,000 | 0 | — | $16.6M | 0.12% | $23.65 |
| Q1 2018 | 700,000 | 0 | — | $15.8M | 0.13% | $22.52 |
| Q4 2017 | 700,000 | 0 | — | $21.8M | 0.19% | $31.18 |
| Q3 2017 | 700,000 | +300,000 | +75.0% | $21.8M | 0.18% | $31.21 |
| Q2 2017 | 400,000 | 0 | — | $6.9M | 0.06% | $17.16 |
| Q1 2017 | 400,000 | 0 | — | $7.0M | 0.06% | $17.51 |
| Q4 2016 | 400,000 | 0 | — | $5.3M | 0.05% | $13.23 |
| Q3 2016 | 400,000 | 1,100,000 | -73.3% | $5.8M | 0.05% | $14.52 |
| Q2 2016 | 1,500,000 | 0 | — | $14.8M | 0.16% | $9.86 |
| Q1 2016 | 1,500,000 | — | — | $19.0M | 0.20% | $12.67 |
Methodology & FAQ
How This Position History Is Sourced
Each row is one SEC Form 13F-HR filing disclosing this position. Share count, market value, and reported quarter are taken verbatim from the filing; portfolio weight is recomputed against the same filing's total reported equity book. Implied price-per-share is market value divided by shares — a quarter-end mark, not the manager's cost basis. See the full methodology document for the normalization rules.
When did BAKER BROS. ADVISORS LP first disclose a INSM position in 13F-HR filings?
BAKER BROS. ADVISORS LP first reported INSMED INCORPORATED (INSM) on its 13F-HR filing for the period ending 2016-03-31 (Q1 2016). The position has appeared on 41 reported quarters within Pactolio's tracked window.
What was BAKER BROS. ADVISORS LP's most recent quarter-over-quarter share-count change in INSM?
Between Q4 2025 and Q1 2026, BAKER BROS. ADVISORS LP added 828,365 shares of INSM (+12.6%), bringing the total reported position to 7,421,111 shares at a market value of $1.21B.
Does the implied price-per-share represent BAKER BROS. ADVISORS LP's cost basis in INSM?
No. The implied price-per-share column is the 13F-HR reported market value divided by reported share count on the filing date (end of quarter). It is a quarter-end mark, not a cost basis or transaction price. Use it as a sanity check on the value column, not as an indicator of the manager's entry or exit price.