ORUKA THERAPEUTICS (ORKA) — Institutional Holders & Hedge Fund Ownership
ORUKA THERAPEUTICS (ORKA) institutional ownership: 5 hedge funds and institutional investors, holding 7.3M shares ($373.5M), as of Q1 2026, per SEC Form 13F-HR filings.
Track who bought and sold ORUKA THERAPEUTICS (ORKA) this quarter — every hedge fund, family office, and institutional investor that filed an SEC Form 13F-HR for ORKA is aggregated here. Pactolio aggregates these SEC Form 13F-HR filings into one view: top institutional holders, biggest QoQ buyers and sellers, and consolidated ownership changes for ORKA.
The top ORKA shareholders by portfolio weight are Avidity (11.77%), Paradigm Biocapital Advisors (2.33%), and Deep Track (2.06%). In Q1 2026, Avidity made the largest position increase (+6.00%).
Top 5 Institutional Holders of ORUKA THERAPEUTICS (ORKA) — Q1 2026
| # | Fund | Shares | Market Value | Portfolio Weight |
|---|---|---|---|---|
| 1 | Avidity | 760,424 | $52.0M | 11.77% |
| 2 | Paradigm Biocapital Advisors | 2,320,316 | $113.8M | 2.33% |
| 3 | Deep Track | 2,034,203 | $99.8M | 2.06% |
| 4 | Jones Hill | 140,843 | $6.9M | 1.48% |
| 5 | RTW Investments | 2,058,148 | $101.0M | 1.00% |
- 5Hedge funds holding
- 7,313,934Shares held (disclosed)
- $373.5M13F market value
- 2.06%Median portfolio weight
Ownership History
Quarter-by-quarter share count, market value, and portfolio conviction weight (up to 5 of the heaviest weight-by-portfolio funds) of ORKA. Sourced from 13F filings; reflects long equity positions only.
Quarter-over-Quarter ActivityQ1 2026
The biggest weight-increase and weight-decrease changes among funds that hold ORKA. Deltas compare the selected filing to the previous reporting quarter.
Top buyers
- Avidity+6.00% · +100,000 shares
- Jones Hill+1.48% · +140,843 shares
- Paradigm Biocapital Advisors+0.94% · +610,000 shares
Top sellers
- Commodore Capital-3.54% · -1,753,054 shares
- Avoro Capital Advisors-0.40% · -1,333,340 shares
- Viking Global-0.21% · -2,666,690 shares
Ownership Statistics
- Funds holding
- 5
- Median weight
- 2.06%
- Largest holder
- Avidity · 11.77%
- Smallest holder
- RTW Investments · 1.00%
- Shares held
- 7,313,934 (-5,029,548)
All Institutional HoldersSortable · searchable
All institutional investors (Max 50) holding ORKA in the selected quarter. Click a fund name to drill into its full 13F portfolio.
| 1 | Avidity | 760,424 | $52.0M | 11.77% |
| 2 | Paradigm Biocapital Advisors | 2,320,316 | $113.8M | 2.33% |
| 3 | Deep Track | 2,034,203 | $99.8M | 2.06% |
| 4 | Jones Hill | 140,843 | $6.9M | 1.48% |
| 5 | RTW Investments | 2,058,148 | $101.0M | 1.00% |
Methodology & FAQ
Methodology: How We Track ORKA Institutional Holdings
Our data is systematically aggregated directly from quarterly Form 13F-HR disclosures submitted to the U.S. Securities and Exchange Commission (SEC).
- Who Must File (Reporting Threshold): This dataset includes filings from U.S. institutional investment managers, hedge funds, mutual funds, university endowments, and family offices managing at least $100 million in Section 13(f) securities (including equities, options, convertibles, ETFs, and warrants).
- What is Included (Data Scope): We capture long positions in Section 13(f) securities for ORUKA THERAPEUTICS INC (ORKA). By SEC regulation, 13F filings do not require the disclosure of short positions, non-U.S. holdings, or OTC derivatives. Listed options are excluded from portfolio weight calculations to ensure comparability across filers.
- Portfolio Weight Explained (Metric Definition): “Portfolio Weight” shows how much of a fund's total reported 13F portfolio value (excluding listed options) is allocated to ORKA on the specific reporting date.
- How to Use This Data (Interpretation): Quarter-over-quarter changes in shares and portfolio weight reflect a combination of active trading and market price movements. These are descriptive metrics of fund allocation, not explicit buy or sell signals.
How do you measure hedge fund conviction and institutional concentration in ORKA?
We evaluate fund conviction by looking at portfolio weight rather than just absolute share count. By tracking how the largest holders —such as Avidity , Paradigm Biocapital Advisors , and Deep Track as of Q1 2026— change their position sizing quarter-over-quarter, we help investors distinguish between deliberate position sizing changes and passive mark-to-market drift.
Does the ORKA ownership data include short interest or options?
SEC Form 13F mandates the disclosure of long positions in Section 13(f) securities, which includes equities and listed options (put and call contracts), but excludes short interest, swaps, and OTC derivatives by regulatory design. On this platform, listed options are excluded from portfolio weight calculations to ensure comparability across filers.
Are family offices and university endowments included in this ORKA data?
Yes. In addition to traditional hedge funds and large asset managers, any institutional entity exercising investment discretion over at least $100 million in Section 13(f) securities must file a Form 13F. This explicitly includes single-family offices and university endowments. If a qualifying family office or endowment holds ORKA stock, their allocation is systematically aggregated alongside traditional fund data.
When is the institutional ownership data updated, and is there a reporting lag?
Institutional investment managers are required to file their Form 13F within 45 days after the end of a calendar quarter (the standard “T+45” window). Our platform re-ingests new filings from the SEC EDGAR database on a nightly cycle, typically within 24–48 hours of publication, providing a point-in-time snapshot of reported consensus positioning for ORKA as of each filing date.