TWIST BIOSCIENCE (TWST) — Institutional Holders & Hedge Fund Ownership
TWIST BIOSCIENCE (TWST) institutional ownership: 2 hedge funds and institutional investors, holding 230K shares ($10.9M), as of Q1 2026, per SEC Form 13F-HR filings.
TWIST BIOSCIENCE (TWST) appears in the 13F portfolios of dozens of professional money managers each quarter; the aggregated filings surface top buyers, top sellers, and conviction-weighted holders for TWST. These filings are aggregated to surface top holders, quarterly buyers and sellers, position changes, and peer-fund overlap.
The top TWST shareholders by portfolio weight are Duquesne Family Office (0.33%) and Polen Capital Management (0.01%). In Q1 2026, Duquesne Family Office made the largest position increase (+0.33%).
Top 2 Institutional Holders of TWIST BIOSCIENCE (TWST) — Q1 2026
| # | Fund | Shares | Market Value | Portfolio Weight |
|---|---|---|---|---|
| 1 | Duquesne Family Office | 206,000 | $9.8M | 0.33% |
| 2 | Polen Capital Management | 24,037 | $1.1M | 0.01% |
- 2Hedge funds holding
- 230,037Shares held (disclosed)
- $10.9M13F market value
- 0.17%Median portfolio weight
Ownership History
Quarter-by-quarter share count, market value, and portfolio conviction weight (up to 5 of the heaviest weight-by-portfolio funds) of TWST. Sourced from 13F filings; reflects long equity positions only.
Quarter-over-Quarter ActivityQ1 2026
The biggest weight-increase and weight-decrease changes among funds that hold TWST. Deltas compare the selected filing to the previous reporting quarter.
Top buyers
- Duquesne Family Office+0.33% · +206,000 shares
- Polen Capital Management+0.01% · +24,037 shares
Top sellers
No notable sellers this quarter.
Ownership Statistics
- Funds holding
- 2
- Median weight
- 0.17%
- Largest holder
- Duquesne Family Office · 0.33%
- Smallest holder
- Polen Capital Management · 0.01%
- Shares held
- 230,037 (+230,037)
All Institutional HoldersSortable · searchable
All institutional investors (Max 50) holding TWST in the selected quarter. Click a fund name to drill into its full 13F portfolio.
| 1 | Duquesne Family Office | 206,000 | $9.8M | 0.33% |
| 2 | Polen Capital Management | 24,037 | $1.1M | 0.01% |
Methodology & FAQ
Methodology: How We Track TWST Institutional Holdings
Our data is systematically aggregated directly from quarterly Form 13F-HR disclosures submitted to the U.S. Securities and Exchange Commission (SEC).
- Who Must File (Reporting Threshold): This dataset includes filings from U.S. institutional investment managers, hedge funds, mutual funds, university endowments, and family offices managing at least $100 million in Section 13(f) securities (including equities, options, convertibles, ETFs, and warrants).
- What is Included (Data Scope): We capture long positions in Section 13(f) securities for TWIST BIOSCIENCE CORP (TWST). By SEC regulation, 13F filings do not require the disclosure of short positions, non-U.S. holdings, or OTC derivatives. Listed options are excluded from portfolio weight calculations to ensure comparability across filers.
- Portfolio Weight Explained (Metric Definition): “Portfolio Weight” shows how much of a fund's total reported 13F portfolio value (excluding listed options) is allocated to TWST on the specific reporting date.
- How to Use This Data (Interpretation): Quarter-over-quarter changes in shares and portfolio weight reflect a combination of active trading and market price movements. These are descriptive metrics of fund allocation, not explicit buy or sell signals.
How do you measure hedge fund conviction and institutional concentration in TWST?
We evaluate fund conviction by looking at portfolio weight rather than just absolute share count. By tracking how the largest holders —such as Duquesne Family Office and Polen Capital Management as of Q1 2026— change their position sizing quarter-over-quarter, we help investors distinguish between deliberate position sizing changes and passive mark-to-market drift.
Does the TWST ownership data include short interest or options?
SEC Form 13F mandates the disclosure of long positions in Section 13(f) securities, which includes equities and listed options (put and call contracts), but excludes short interest, swaps, and OTC derivatives by regulatory design. On this platform, listed options are excluded from portfolio weight calculations to ensure comparability across filers.
Are family offices and university endowments included in this TWST data?
Yes. In addition to traditional hedge funds and large asset managers, any institutional entity exercising investment discretion over at least $100 million in Section 13(f) securities must file a Form 13F. This explicitly includes single-family offices and university endowments. If a qualifying family office or endowment holds TWST stock, their allocation is systematically aggregated alongside traditional fund data.
When is the institutional ownership data updated, and is there a reporting lag?
Institutional investment managers are required to file their Form 13F within 45 days after the end of a calendar quarter (the standard “T+45” window). Our platform re-ingests new filings from the SEC EDGAR database on a nightly cycle, typically within 24–48 hours of publication, providing a point-in-time snapshot of reported consensus positioning for TWST as of each filing date.