Darwin Global Management, Ltd. 13F: Quarter-over-Quarter Portfolio Changes
Darwin Global Management, Ltd. reported a disclosed portfolio value of approximately $3.8 billion in its latest SEC Form 13F-HR filing for Q2 2026, down 0.3% quarter on quarter. Over the quarter, the fund bought more shares in 3 holdings, trimmed 2 holdings, and exited 1 position.
Darwin Global Management, Ltd.'s top buy was Revolution Medicines INC (RVMD) . The fund bought 380.8% more shares, lifting the position's portfolio weight by 49.0 percentage points. Its top sell was Insmed INC (INSM) . The fund sold 61.7% of its previously reported shares, reducing the position's portfolio weight by 50.4 percentage points.
Top BuysQ2 2026
The fund's top buys among existing positions in Q2 2026. Ranked by portfolio-weight impact, with the percentage of additional shares shown separately.
| Company | Ticker | Portfolio Weight Change | More Shares | History |
|---|---|---|---|---|
| REVOLUTION MEDICINES INC | RVMD | +49.0% | +380.8% | History → |
| ABIVAX SA | ABVX | +-0.1% | +4.4% | History → |
| BELITE BIO INC | BLTE | +0.0% | +0.6% | History → |
Top SellsQ2 2026
The fund's top sells among positions it retained in Q2 2026. Ranked by portfolio-weight impact. Full exits are listed separately.
| Company | Ticker | Portfolio Weight Change | Shares Sold | History |
|---|---|---|---|---|
| INSMED INC | INSM | -50.4% | 61.7% | History → |
| ROIVANT SCIENCES LTD | ROIV | 1.5% | 0.7% | History → |
Full ExitsQ2 2026
Positions present in the prior 13F-HR filing that no longer appear in Q2 2026.
| Company | Ticker | Last-Reported Portfolio Weight |
|---|---|---|
| DIANTHUS THERAPEUTICS INC | DNTH | 0.0% |
Net Portfolio Value ChangeQ2 2026
- $3.8BPrior quarter
- $3.8BCurrent quarter
- $-0.0BNet delta
- -0.3%% change
Methodology & FAQ
How Darwin Global Management, Ltd. Quarterly Changes Are Computed
All deltas are sourced from sequential SEC Form 13F-HR filings for Darwin Global Management, Ltd.: each row joins the most recent filing against the immediately preceding quarterly filing for the same fund. Share-count changes reflect reported trading activity, while portfolio weights can also move because of market price changes. Portfolio weights are normalized to exclude listed options for comparability. A complete description, including how confidential treatment filings are handled, is documented in the Methodology.
What stocks did Darwin Global Management, Ltd. buy in Q2 2026?
In Q2 2026, Darwin Global Management, Ltd. bought more shares of REVOLUTION MEDICINES INC (RVMD), ABIVAX SA (ABVX), BELITE BIO INC (BLTE).
What stocks did Darwin Global Management, Ltd. sell in Q2 2026?
In Q2 2026, Darwin Global Management, Ltd. fully sold 1 position (DIANTHUS THERAPEUTICS INC (DNTH)); reduced holdings in INSMED INC (INSM), ROIVANT SCIENCES LTD (ROIV).
Which positions did Darwin Global Management, Ltd. initiate in Q2 2026?
Darwin Global Management, Ltd. established no new positions in Q2 2026.
Which existing positions saw the largest allocation increases for Darwin Global Management, Ltd. in Q2 2026?
Of 3 existing positions with share-count increases in Q2 2026, the largest were: REVOLUTION MEDICINES INC (RVMD, +49.0% weight, +380.8% shares), ABIVAX SA (ABVX, +-0.1% weight, +4.4% shares), BELITE BIO INC (BLTE, +0.0% weight, +0.6% shares).
Which positions did Darwin Global Management, Ltd. fully exit in Q2 2026?
Darwin Global Management, Ltd. fully exited 1 position in Q2 2026: DIANTHUS THERAPEUTICS INC (DNTH, last-reported weight 0.0%).
Which existing positions saw the largest allocation reductions for Darwin Global Management, Ltd. in Q2 2026?
Of 2 existing positions with share-count reductions in Q2 2026, the largest were: INSMED INC (INSM, -50.4% weight, -61.7% shares), ROIVANT SCIENCES LTD (ROIV, 1.5% weight, -0.7% shares).
Do quarter-over-quarter 13F allocation changes constitute explicit trading signals?
No. Quarter-over-quarter changes reflect a combination of active trading and market price movement. A weight increase can result from price appreciation alone, without the manager adding shares. Share-count delta is the cleaner indicator of explicit trading activity. All deltas on this page are sourced from sequential SEC Form 13F-HR filings.