Samsara BioCapital, LLC 13F: Portfolio & Holdings
Samsara BioCapital, LLC (SEC CIK 0001744967) reported 22 positions with a combined market value of $1.0 billion in its most recent SEC Form 13F-HR filing (as of Q1 2026). The Palo Alto-based hedge fund maintains a highly concentrated portfolio with a Healthcare sector tilt, which represents 100.0% of its exposure.
Its largest holdings are Scholar Rock Hldg CORP (SRRK) at 32.9%, Mineralys Therapeutics INC (MLYS) at 15.5%, and Alumis INC (ALMS) at 13.6%.
The largest new position was Spyglass Pharma INC (SGP) at 5.3% of the portfolio. See the fund’s full Q1 2026 buys, sells, and portfolio changes →
Based on published SEC 13F filings, SAMSARA BIOCAPITAL's closest peer funds by portfolio overlap are Saturn V Capital Management LP (28.5%), Caligan Partners LP (18.8%), and Paradigm Biocapital Advisors LP (17.1%).
- 13F AUM
- $1.0B
- Equity Positions
- 22
- Top-10 Concentration
- 92.0%
- Largest Sector · 100.0%
- Healthcare
- Longest-Held Position · 28 qtrs
- SYN_869367102
- Median Holding Period
- 7 Qtrs
What are SAMSARA BIOCAPITAL’s largest 13F holdings as of Q1 2026?
Largest 13F positions disclosed by SAMSARA BIOCAPITAL, ranked by portfolio weight. Full multi-quarter history and the broader institutional holder base for each ticker linked per row.
| # | Issuer | Ticker | Sector | Weight | Position Value | Detail |
|---|---|---|---|---|---|---|
| 1 | SCHOLAR ROCK HLDG CORP | SRRK | Healthcare | 32.9% | $339.1M | Position History All Holders |
| 2 | MINERALYS THERAPEUTICS INC | MLYS | Healthcare | 15.5% | $159.0M | Position History All Holders |
| 3 | ALUMIS INC | ALMS | Healthcare | 13.6% | $139.8M | Position History All Holders |
| 4 | SEPTERNA INC | SEPN | Healthcare | 7.4% | $75.7M | Position History All Holders |
| 5 | KALARIS THERAPEUTICS INC | KLRS | Healthcare | 7.3% | $74.7M | Position History All Holders |
| 6 | SPYGLASS PHARMA INC NEW | SGP | Healthcare | 5.3% | $54.7M | Position History All Holders |
| 7 | NEUROGENE INC | NGNE | Healthcare | 3.4% | $34.6M | Position History All Holders |
| 8 | INVENTIVA SA | IVA | Healthcare | 2.8% | $28.8M | Position History All Holders |
| 9 | SUTRO BIOPHARMA INC | STRO | Healthcare | 2.6% | $26.5M | Position History All Holders |
| 10 | JADE BIOSCIENCES INC | JBIO | Healthcare | 1.3% | $13.6M | Position History All Holders |
View SAMSARA BIOCAPITAL's Q1 2026 portfolio changes and trading report →
Portfolio composition
Sectors, concentrations, and a tap-through treemap of every position in the fund's latest 13F.
Holding period analytics
Distribution of holding periods for all 141 stocks the fund has ever held (up to selected quarter):
Which Funds Hold a Similar Portfolio to SAMSARA BIOCAPITAL?
Ranked by percentage of the peer fund's 13F equity portfolio that overlaps with SAMSARA BIOCAPITAL's positions in Q1 2026.
| # | Fund | Shared Positions | Overlap % |
|---|---|---|---|
| 1 | Saturn V Capital Management LP | 3 | 28.5% |
| 2 | Caligan Partners LP | 3 | 18.8% |
| 3 | Paradigm Biocapital Advisors LP | 5 | 17.1% |
| 4 | Octagon Capital Advisors LP | 3 | 15.5% |
| 5 | Kite Lake Capital Management (UK) LLP | 1 | 11.2% |
| 6 | Trails Edge Capital Partners, LP | 4 | 11.0% |
| 7 | Avidity Partners Management LP | 2 | 9.8% |
| 8 | Darwin Global Management, Ltd. | 1 | 9.3% |
| 9 | Vestal Point Capital, LP | 3 | 7.0% |
| 10 | Davern Capital Partners, LP | 2 | 5.7% |
How Has SAMSARA BIOCAPITAL's AUM Changed Over Time?
Quarterly 13F-reported AUM for SAMSARA BIOCAPITAL, derived from aggregate reported position market values disclosed to the U.S. SEC.
| Quarter | 13F AUM (USD) | QoQ Change |
|---|---|---|
| Q4 2018 | $104M | — |
| Q1 2019 | $127M | +0.0B |
| Q2 2019 | $151M | +0.0B |
| Q3 2019 | $147M | -0.0B |
| Q4 2019 | $209M | +0.1B |
| Q1 2020 | $174M | -0.0B |
| Q2 2020 | $311M | +0.1B |
| Q3 2020 | $359M | +0.0B |
| Q4 2020 | $994M | +0.6B |
| Q1 2021 | $497M | -0.5B |
| Q2 2021 | $761M | +0.3B |
| Q3 2021 | $602M | -0.2B |
| Q4 2021 | $502M | -0.1B |
| Q1 2022 | $395M | -0.1B |
| Q2 2022 | $374M | -0.0B |
| Q3 2022 | $428M | +0.1B |
| Q4 2022 | $461M | +0.0B |
| Q1 2023 | $486M | +0.0B |
| Q2 2023 | $570M | +0.1B |
| Q3 2023 | $327M | -0.2B |
| Q4 2023 | $643M | +0.3B |
| Q1 2024 | $646M | +0.0B |
| Q2 2024 | $478M | -0.2B |
| Q3 2024 | $520M | +0.0B |
| Q4 2024 | $729M | +0.2B |
| Q1 2025 | $561M | -0.2B |
| Q2 2025 | $489M | -0.1B |
| Q3 2025 | $766M | +0.3B |
| Q4 2025 | $969M | +0.2B |
| Q1 2026 | $1.0B | +0.1B |
Methodology & FAQ
How We Track SAMSARA BIOCAPITAL Holdings
Our data is systematically aggregated directly from quarterly Form 13F-HR disclosures submitted to the U.S. Securities and Exchange Commission (SEC).
- Who Must File (Reporting Threshold): This dataset includes filings from U.S. institutional investment managers, hedge funds, mutual funds, university endowments, and family offices managing at least $100 million in Section 13(f) securities (including equities, options, convertibles, ETFs, and warrants).
- What is Included (Data Scope): By regulation, 13F filings include long positions in U.S. exchange-listed stocks, ETFs, shares of closed-end investment companies, and convertible debt, as defined in the SEC's official Section 13(f) securities list . For listed options (calls/puts) the reported value is based on the notional value.
- Portfolio Weight Explained (Metric Definition): “Portfolio Weight” shows how much of a fund's total reported 13F portfolio value (excluding listed options) is allocated to a specific position on the reporting date.
- How to Use This Data (Interpretation): Quarter-over-quarter changes in shares and portfolio weight reflect a combination of active trading and market price movements. These are descriptive metrics of fund allocation, not explicit buy or sell signals.
What does SAMSARA BIOCAPITAL's 13F filing disclose about their portfolio?
A Form 13F-HR filed by SAMSARA BIOCAPITAL with the U.S. SEC discloses all long positions in Section 13(f) securities — U.S.-listed equities, ETFs, closed-end funds, and listed put/call options — held at quarter-end with a market value of at least $200,000 or 10,000 or more shares. Pactolio aggregates these filings to surface the manager’s reported portfolio weights, share counts, and quarter-over-quarter portfolio changes in a structured format. The filing represents a point-in-time snapshot of disclosed long-side exposure, not a real-time or complete view of the fund’s total book.
How do you measure conviction in SAMSARA BIOCAPITAL's portfolio allocations?
Conviction is measured by portfolio weight — the percentage of SAMSARA BIOCAPITAL’s total reported 13F market value allocated to a given position — rather than by absolute share count or dollar value alone. A position representing a disproportionately large share of the fund’s disclosed book signals high-conviction allocation, regardless of whether it ranks among the fund’s largest absolute holdings.
What is excluded from SAMSARA BIOCAPITAL's 13F — short positions, swaps, and derivatives?
SEC Form 13F requires disclosure of long positions only. Specifically excluded are: short interest, total return swaps, credit default swaps, and all OTC derivatives — none of which appear in 13F filings regardless of position size. Listed put and call options must be disclosed but are excluded from portfolio weight calculations on this platform so that reported weights reflect direct equity exposure and remain comparable across filers. This means SAMSARA BIOCAPITAL’s 13F represents the reported long book, which may differ materially from its net economic exposure.
When is SAMSARA BIOCAPITAL's 13F data available, and how large is the reporting lag?
Investment managers must submit Form 13F within 45 calendar days of each quarter-end (the T+45 deadline). Pactolio ingests filings directly from SEC EDGAR as they are published — managers who file early appear in our system before the deadline, while late filers are captured on their actual filing date. The quarter label shown at the top of this page reflects the most recently processed 13F cycle for SAMSARA BIOCAPITAL. The inherent reporting lag means the data always reflects positions as of the prior quarter-end, not current holdings.
Who must file a Form 13F with the SEC, and does SAMSARA BIOCAPITAL qualify?
Under SEC Rule 13f-1, any investment manager — including hedge funds, family offices, registered investment advisers, pension funds, and university endowments — that exercises investment discretion over $100 million or more in Section 13(f) securities at any point during a calendar year must file Form 13F for that year. SAMSARA BIOCAPITAL meets this threshold, which is why its holdings are publicly disclosed and accessible on this platform. The $100 million threshold is evaluated on a rolling basis, meaning new filers can enter and existing filers can exit the disclosure regime as AUM crosses that boundary.